CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats
نویسندگان
چکیده
Azhar Masood, Man Yi, Rosetta Belcastro, Jun Li, Lianet Lopez, Crystal Kantores, Robert P. Jankov, and A. Keith Tanswell Lung Biology Programme, Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; and Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, Toronto, Ontario, Canada
منابع مشابه
Neutrophil elastase-induced elastin degradation mediates macrophage
23 Neutrophil (PMNL) influx precedes lung macrophage (LM) influx into the lung following 24 exposure of newborn pups to 60% O2. We hypothesized that PMNL were responsible for the 25 signals leading to LM influx. This was confirmed when inhibition of PMNL influx with a CXC 26 chemokine receptor-2 antagonist, SB-265610, also prevented the 60% O2-dependent LM influx, 27 LM-derived nitrotyrosine fo...
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